3-Hydroxy-5-(trifluoromethyl)benzoic acid

3-Hydroxy-5-(trifluoromethyl)benzoic acid - Names and Identifiers

Name	3-Hydroxy-5-(trifluoromethyl)benzoic acid
Synonyms	-Carboxy-5-(trifluoromethyl)phenol 3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID 3-Hydroxy-5-(trifluoromethyl)benzoic acid Benzoic acid, 3-hydroxy-5-(trifluoromethyl)- 3-Carboxy-5-(trifluoromethyl)phenol, 3-Carboxy-5-hydroxybenzotrifluoride
CAS	328-69-8
InChI	InChI=1/C8H5F3O3/c9-8(10,11)5-1-4(7(13)14)2-6(12)3-5/h1-3,12H,(H,13,14)

3-Hydroxy-5-(trifluoromethyl)benzoic acid - Physico-chemical Properties

Molecular Formula	C8H5F3O3
Molar Mass	206.12
Density	1.539±0.06 g/cm3(Predicted)
Melting Point	191-193°C
Boling Point	333.7±42.0 °C(Predicted)
Flash Point	155.6°C
Vapor Presure	5.32E-05mmHg at 25°C
Appearance	Crystalline powder
pKa	3.65±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.509
MDL	MFCD07368783

3-Hydroxy-5-(trifluoromethyl)benzoic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

3-Hydroxy-5-(trifluoromethyl)benzoic acid - Introduction

3-Hydroxy-5-(trifluoromethyl)benzoic acid is an organic compound with the chemical formula C8H5F3O3.

The properties of the compound are as follows:
Appearance: Colorless crystalline or white crystalline solid.
Melting Point: 156-158 ℃
Boiling point: 344.3 ℃
Solubility: Soluble in ethanol, acetone and dimethyl sulfoxide, slightly soluble in water.

The compound has multiple uses:
1. Chemical Synthesis: can be used as an important intermediate in organic synthesis, used in the preparation of other organic compounds.
2. Drug research: It has certain application value in drug research, such as for the synthesis of drugs or drug intermediates.
3. Dyes and pigments: can be used as synthetic raw materials for dyes and pigments.

The preparation method of 3-Hydroxy-5-(trifluoromethyl)benzoic acid is as follows:
The compound can be synthesized by the reaction of p-trifluoromethylphenol and chloroformic acid.

When using, storing and handling 3-Hydroxy-5-(trifluoromethyl)benzoic acid, pay attention to its safety information:
1. It is an organic compound that is irritating and corrosive and needs to avoid contact with the skin, eyes and respiratory system.
2. In the process of operation, should wear protective glasses, protective gloves and protective masks and other personal protective equipment.
3. In storage, should be sealed to avoid contact with oxygen, acid, alkali and other substances.
4. Waste shall be disposed of in accordance with relevant laws and regulations and shall not be discharged into the environment at will.

Last Update：2024-04-09 19:05:49